Effect of Sleeve Gastrectomy on Pancreatic Exocrine Insufficiency.
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- Pancreatic excorine enzyme difference
研究概览
简要总结
Main proposed benefit of sleeve gastrectomy is loss of ghrelin secreting tissue. Some studies express that ghrelin augment pancreatic regeneration. Therefore we hypothesized that with sleeve gastrectomy it may result with pancreatic insufficiency.
详细描述
Mechanism of weight loss differs in bariatric surgery according to type of surgery.
With sleeve gastrectomy which has restrictive mechanism, ghrelin excretion decreases, and this condition is attributed as an additional mechanism in weight loss.
Ghrelin effects pancreatic regeneration, and loss of ghrelin may result with pancreatic insufficiency. Therefore we aimed to deteremine this association.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients underwent bariatric surgery (Sleeve gastrectomy) after concordonce with NIH criteria
排除标准
- •Additional operations to sleeve gastrectomy like duodenal switch. Other bariatric operations.
结局指标
主要结局
Pancreatic excorine enzyme difference
时间窗: post operative 3 months
Effect of operation on pancreatic excorine enzyme
次要结局
未报告次要终点
研究者
Fatih Basak
M.D.
Umraniye Education and Research Hospital