Magnesium variability study in haemodialysis patients: <br>intra-patient and inter-patient variability of plasma magnesium before and after hemodialysis.<br>

Completed

Conditions: endstage renal disease
kidney disease
10082206
10029149
10003216

Registration Number: NL-OMON42883

Lead Sponsor: Vrije Universiteit Medisch Centrum

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 30

Inclusion Criteria

- Age *18
- Hemodialysis with regular three times weekly dialysis schedule
- Hemodialysis since at least 3 months
- Standard dialysate Mg2+ 0.5 mmol/L
- Providing informed consent

Exclusion Criteria

- Age <18
- Intravenous magnesium supplementation that has been started or stopped in the last 2 weeks, or the subject currently receives non-continuous magnesium supplementation. Note: subjects receiving stable continuous intravenous magnesium supplementation including total parenteral nutrition since at least 2 weeks can be included.
- Expected cessation of dialysis treatment within 2 weeks after inclusion.

Study & Design

Study Type: Observational non invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Main parameters: Plasma Mg before and after dialysis in 6 consecutive<br /><br>hemodialysis sessions, determined in duplicate.<br /><br>Main endpoints: The intra-individual pre-dialysis variability and post-dialysis<br /><br>(dialysis-induced) variability of plasma Mg and the interindividual variability<br /><br>of pre-dialysis and post-dialysis plasma Mg. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>- The difference in point-estimate of plasma Mg concentration before and after<br /><br>dialysis, using a fixed standard dialysate Mg concentration, as a function of<br /><br>predialysis Mg concentration.<br /><br>- Factors that predict larger differences in point-estimates of plasma Mg<br /><br>before and after dialysis. </p><br>