A randomized phase II study of secondary cytoreductive surgery in patients with relapsed ovarian cancer who have progressed on PARP inhibitor maintenance

Koera University Guro Hospital0 个研究点目标入组 124 人开始时间: 待定最近更新: 2023年8月21日

研究概览

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•Patients with first recurrence of platinum sensitive, invasive epithelial ovarian-, fallopian tube- or primary peritoneal cancer of any initial stage.
•-Progression-free interval of at least 6 months after end of last platinum- containing therapy,
•-Progressed during PARP inhibitor maintenance or treatment free interval biologic agent (TFIb) < 3 months
•-Women aged = 19 years
•-Complete resection of the tumor by median laparotomy seems possible (estimated by an experienced surgeon). Intra-abdominal disease has to be excluded by MRI/CT, if other surgical approaches for isolated extra-abdominal recurrences are planned
•1.A positive AGO-score and/or iMODEL+PET/CT
•2.Patients who are likely to be completely resected according to the investigator's judgment will be allowed by consensus between PI(surgeon) and designated radiologist even if AGO or iMODEL+PET/CT negative.
•-Patients who have given their signed and written informed consent and their consent to data transmission and -processing.

•-Patients without recurrence who are scheduled for diagnostic/second-look surgery or debulking surgery after completion of chemotherapy
•-Patients with non-epithelial tumors as well as borderline tumors
•-More than one prior chemotherapy
•-Patients who are ineligible for pegylated liposomal doxorubicin or carboplatin
•-Patients with second, third, or later recurrence
•-Patients with second malignancies who have been treated by laparotomy, as well as other neoplasms, if the treatment might interfere with the treatment of relapsed ovarian cancer or if major impact on prognosis is expected.
•-Patients with so-called platinum-refractory tumor, i.e. progression during chemotherapy or recurrence within 6 months after end of former first platinum- containing therapy
•-Only palliative surgery planned
•-Radiological signs suggesting metastases not accessible to surgical removal (i.e. complete resection is deemed impossible)
•-Any concomitant disease not allowing surgery and/or chemotherapy
•-Any medical history indicating excessive peri-operative risk
•-Any current medication inducing considerable surgical risk (e.g. bleeding: due to oral anticoagulating agents, bevacizumab)
•-No assessable archival tumor tissue

发起方

Koera University Guro Hospital