The Randomly Controlled Trial of Optimal Surgical Method for CAD Patients Combined Moderate Functional Ischemic Mitral Regurgitation
概览
- 阶段
- 不适用
- 干预措施
- 未指定
- 疾病 / 适应症
- Coronary Artery Disease
- 发起方
- Beijing Anzhen Hospital
- 入组人数
- 80
- 试验地点
- 1
- 主要终点
- Left Ventricular End Systolic Volume Index (LVESVI)
- 最后更新
- 7年前
概览
简要总结
Coronary artery bypass grafting(CABG) is an effective procedure in treating severe coronary artery disease(CAD). Optimal surgical method for CAD patients with functional ischemic mitral regurgitation(FIMR) is still controversial. This study will evaluate the different effectiveness of CABG plus mitral valve annuloplasty versus CABG alone on patients with moderate FIMR.
详细描述
CAD is a severe health problem worldwide. It is a result of plaque buildup, and eventually leads to the reduction of blood supply on myocardium. CABG is one of the procedure to improve symptoms caused by myocardial ischemia. And it is especially effective in treating severe coronary artery disease. FIMR is one of the most common complications of CAD. After acute myocardial infarction, FIMR will occur in 17%-55% patients, and 3%-19% of them will develop into moderate or severe MR eventually. FIMR is an important prognostic factor of CAD, the in-hospital mortality rate of patients with IMR is significantly higher in several studies. In patients with mild MR, CABG alone is enough to improve myocardial ischemia; however, in people with moderate mitral regurgitation, there is still a dispute on whether mitral valve annuloplasty is beneficial at the time of CABG. The purpose of this study is to determine the optimal surgical procedure of CAD patients combined moderate FIMR. This study will compare the effectiveness of different surgical procedure on people with moderate FIMR by enrolling people with enrolling people with CAD who require CABG procedure and have moderate mitral regurgitation. At baseline study, a questionnaire will be assigned to undergo either CABG surgery of CABG plus mitral calve annuloplasty. Blood, urine and tissue samples will be collected after the surgery. All participants will be followed up at month 1,3,6,12, participants will take part in a medication history review, a physical examination, a blood collection to evaluate the brain natriuretic peptide and an echocardiogram.
研究者
Dong Ran
chief of ward No.11,cardiac surgery
Beijing Anzhen Hospital
入排标准
入选标准
- •CAD that is amenable to CABG and a clinical indication for revascularization
- •Moderate mitral regurgitation in the judgment of the clinical site echocardiographer, quantitative guidelines as proposed would be: jet area between 4 cmsq to 8 cmsq, jet area/left atrial area ratio between 20% to 39%
- •Age ≥ 18 years
- •Mitral valve annuloplasty is applicable
排除标准
- •Organic mitral insufficiency caused by rupture of papillary muscle, rheumatic fever, degeneration or infectious endocarditis
- •Jet area of mitral valve cannot be evaluated by echocardiogram
- •In combination of other procedures such as surgery on tricuspid valve, aortic valve, congenital heart diseases or diseases of the thoracic arteries
- •Prior surgical or percutaneous mitral valve repair
- •Contraindication to cardiopulmonary bypass (CPB)
- •Clinical signs of cardiogenic shock at the time of randomization
- •Treatment with medication prior to the surgery
- •Severe, irreversible pulmonary hypertension in the judgment of the investigator
- •Evidence of cirrhosis or liver synthetic failure
- •Recent history of psychiatric disease (including drug or alcohol abuse) that is likely to impair compliance with the study, in the judgment of the investigator
结局指标
主要结局
Left Ventricular End Systolic Volume Index (LVESVI)
时间窗: Measured at month 12
次要结局
- In-hospital death(1 year)
- Operative death(Measured during operation)
- Rehospitalization(1 year)
- Short-term complications(Measured within 1 week after operation)