The Effects of 8 Weeks of Remote Ischaemic Preconditioning Combined With Exercise Training on (Cerebro) Vascular Function.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 20
- 试验地点
- 1
- 主要终点
- Changes in peripheral vascular function
研究概览
简要总结
Remote Ischaemic preconditioning' (RIPC) is defined as short controlled sequences of repeated inflation of a blood pressure cuff on the upper arm (to reduce blood flow) for 5 mins followed by recovery (cuff deflation so blood flows normally again). An intervention consisting of 4 cycles of 5 min of arm cuff inflation followed by deflation performed 3 times per week, spread over 8 weeks has been shown to improve blood vessel function in young individuals without any medical conditions. This is a simple and easily applicable intervention that could help the blood vessels capacity to deliver blood to an organ (e.g. heart or the muscle).It is currently unknown if RIPC combined with exercise training, provides stronger benefits to our blood vessels than RIPC alone. Therefore, the aim of this study is to investigate if combining RIPC with an 8 week exercise training programme improves blood vessel health more than 8 weeks of RIPC alone.
详细描述
A bout of ischaemia using a blood pressure cuff on the upper arm inflated to a pressure of 220 mm Hg for 5 mins followed by reperfusion (deflation of the cuff) is commonly known as remote ischaemic preconditioning (RIPC). Traditionally, RIPC refers to 5 minutes of inflation-5 minutes deflation repeated 4 times. Recent research has investigated the impact of repeated RIPC interventions on cardiovascular health. One previous repeated RIPC intervention, whereby RIPC was performed 3 times per week for eight weeks, identified that RIPC significantly enhanced conduit artery endothelial function and microvascular function.
Exercise training is crucial for a healthy lifestyle, with the World Health Organization recommending that adults aged 18-64 should do at least 150 minutes of moderate aerobic physical activity per week, or at least 75 minutes of vigorous intensity activity. Interestingly, the impact of exercise training on the vasculature is similar to that of repeated RIPC interventions, with reductions in arterial blood pressure, increased in blood flow and improvements in systemic vascular endothelial function. No study has examined if combining exercise and RIPC provides enhanced effects on the vasculature compared to exercise alone.
The aim of this study is to investigate whether combining 8 weeks of exercise and RIPC is more beneficial to systemic vascular function that exercise alone.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Other
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Able to provide written consent.
- •Males and females 18 to 65 years.
- •Body Mass Index >30g/m2 or waist circumference of ≥94cm (male), ≥80cm (female).
- •Raised blood pressure systolic >130 or diastolic >85 mmHg or normal
- •Diagnosed with high cholesterol by GP or normal
排除标准
- •Type 1 or 2 diabetes mellitus
- •Previous myocardial infarction, stroke (including TIA) or thrombosis
- •Diagnosed with Congestive Heart failure
- •Unable to enroll for the duration of the study
- •Pregnancy or lactation period
- •Any arm injury that will prevent application of the RIPC-intervention
研究组 & 干预措施
rIPC and exercise training
Those in the rIPC + exercise group will attend three 50 minute exercise sessions per week for 8 weeks at Liverpool John Moores University and 3 bouts of IPC per week at home at a time of their choice
干预措施: rIPC + Exercise (Other)
rIPC only
Those randomly allocated into the rIPC group will self administer 3 bouts of IPC per week at home at a time of their choice.
干预措施: rIPC only (Other)
结局指标
主要结局
Changes in peripheral vascular function
时间窗: Peripheral vascular function will be assessed before the intervention, after 2 weeks of the intervention and after the end of the 8 week intervention.
Flow mediated dilation will be used to assess endothelial-dependent vasodilation of the brachial artery.
次要结局
- Response to an ischemia re-perfusion injury(Assessments will be performed before the intervention, after 2 weeks of the intervention and after the end of the 8 week intervention.)
- Assessment of cardiorespiratory fitness(Cardiorespiratory fitness will be assessed before and after the 8 week intervention)
- Detect changes in cerebrovascular function(Cerebrovascular function will be assessed before the intervention, after 2 weeks of the intervention and after the end of the 8 week intervention.)