A Randomized Control trial to evaluate the role/efficacy of single dose intravenous Tranexamic acid at the time of induction of anesthesia for post operative seroma formation in para-umbilical hernioplasty at a tertiary care center

Tranexamic acid is a synthetic derivative of the amino acid lysine that exerts an anti-fibrinolytic action, used in the prevention and treatment of excessive bleeding both in primary and secondary care, first described in the 1960s; recent years have seen a resurgence of interest in its use in the management of bleeding and particularly in the context of severe trauma.Intravenous administration of tranexamic acid during major surgery has been shown to reduce postoperative bleeding by 34 percent. Intravenous dose of tranexamic acid (10mg /kg body weight) was usually given with induction of anaesthesia in para-umbilical hernioplasty. To the best of our knowledge, no up-to-date studies act on the effect of tranexamic acid on seroma formation and wound infection after paraumbilical hernioplasty.