Determination of the in Vitro Effects of Cationic Airway Lining Modulators (CALM) on Chronic Obstructive Pulmonary Disease (COPD) Sputum
Completed
- Conditions
- Chronic Obstructive Pulmonary Disease
- Registration Number
- NCT01096173
- Lead Sponsor
- Pulmatrix Inc.
- Brief Summary
This study is intended to be an evaluation of the properties of human sputum collected from patients with COPD. It is hypothesized that cationic airway lining modulators will have beneficial effects on the rheological properties of sputum derived from patients with COPD. Approximately 10 patients with COPD will collect sputum at home for 5 days. Samples will be collected and tested in laboratory tests.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 10
Inclusion Criteria
- Clinical and spirometric diagnosis of COPD
- Smoking history of at least 10 pack yrs
- Sputum production of greater than 2 tablespoons per day by patient report.
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Exclusion Criteria
- a primary diagnosis of asthma or bronchiectasis
- a COPD exacerbation within 4 weeks
- Inability to comply with study procedures.
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Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
VA WNY Healthcare System
🇺🇸Buffalo, New York, United States