Identification of Neuroprognostic Factors for Out-of-hospital Cardiopulmonary Arrest (MIRA29)

Active, not recruiting

• Conditions: Cardiac Arrest; Neurologic Dysfunction; Cognitive Impairment

• Registration Number: NCT06569134
• Lead Sponsor: University Hospital, Brest

Brief Summary

From the informatized prehospital care registry, data will be collected anonymously for all patients' requiring cardiopulmonary resuscitation for an out-of-hospital cardiac arrest within the Norther Finistere sanitary region.

First step of the model derivation will consist in multivariate analysis to extract the most pertinent variates associated with neurological outcome (evaluated using the CPC Score); Second step will consist in the use of artificial intelligence and machine-learning to derive the most discriminant score.

Detailed Description

Not available

Study Timeline

• Study Start: 2022-07-24
• Primary Completion: 2023-01-24
• Status Verified: 2024-08
• Study First Submitted: 2024-08-08
• Study First Submitted QC: 2024-08-21
• Last Update Submitted: 2024-08-21
• Study First Posted: 2024-08-23
• Last Update Posted: 2024-08-23
• Study Completion: 2025-01-24

Recruitment & Eligibility

• Status: ACTIVE_NOT_RECRUITING
• Sex: All
• Target Recruitment: 1200

Inclusion Criteria

• Cardiac arrest requiring cardiopulmonary resuscitation

Exclusion Criteria

• Death before cardiopulmonary resuscitation
• Pediatric Patients

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Cognitive Outcome	From date of randomization until the date of first documented progression or date of death from any cause, whichever came first, assessed up to 24 months	It will be evaluated at the end of the ICU stay using the CPC score; a CPC score equal or below 2 will be considered as a good outcome, while a CPC \> 2 will be considered as a bad outcome

Secondary Outcome Measures

Name	Time	Method
Death OoH	Before hospital arrival	Death after resuscitation during the prehospital care phase
Death at Day 28	28 days after cardiac arrest	Death at Day 28, before or after hospital discharge
Death ICU	During ICU stay	Death within the ICU care

Trial Locations

Locations (2)

CHU de Brest; 🇫🇷 Brest, France

CH des pays de Morlaix; 🇫🇷 Morlaix, France