Effect of strong magnetic fields on the communication between brain and arm after spinal cord injury.

Not Applicable

• Conditions: spinal cord injury; Injuries and Accidents - Other injuries and accidents; Neurological - Other neurological disorders

• Registration Number: ACTRN12620000746932
• Lead Sponsor: Dr. Onno van der Groen

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2020-07-20
• Last Update Posted: 9 January 2023

Recruitment & Eligibility

• Status: Stopped early
• Sex: All
• Target Recruitment: 4

Inclusion Criteria

Minimum 18 years of age
Chronic stage (>1 year post-injury)
Cervical injury level
Traumatic lesion
Residual upper limb motor deficit with muscle weakness
No joint-related limitation of passive range of movement of the elbow
Presence of MEPs in the arm (assessed during the first visit)
Able to read and understand English

Exclusion Criteria

Evidence of trauma-related brain injury
Pre-injury neurological condition affecting motor or sensory systems
Contraindications for TMS
Medically unstable

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Resting motor threshold (cortical excitability), assessed via Transcranial Magnetic Stimulation and this response to TMS is measured EMG at the muscle.[Once before and after each rTMS condition (sham, low intensity and peri-threshold intensity). ];MEP amplitude at 120% RMT, assessed with Transcranial Magnetic Stimulation. This response to TMS is measured with EMG at the muscle.[Once before and after each rTMS condition (sham, low intensity and peri-threshold intensity). ];M-waves, assessed through peripheral nerve stimulation and the recorded EMG response in response to this stimulation. [Once before and after each rTMS condition (sham, low intensity and peri-threshold intensity). ]