Comparative Assessment of Chitosan-Based Dressing, Ankaferd and Tranexamic Acid in Achieving Hemostasis and Healing Following Dental Extraction in Liver Pre-Transplant Children
Overview
- Phase
- Early Phase 1
- Intervention
- Chitosan
- Conditions
- Liver Cirrhosis
- Sponsor
- British University In Egypt
- Enrollment
- 39
- Locations
- 1
- Primary Endpoint
- To assess the hemostatic effect of chitosan-based dressing, Ankaferd and Tranexamic acid after extraction in children with end stage liver diseases
- Status
- Completed
- Last Updated
- last year
Overview
Brief Summary
The aim of the present study is:
To assess the hemostatic effect of chitosan-based dressing, Ankaferd and Tranexamic acid after extraction in children with end stage liver diseases where the:
• Primary objective: is to evaluate which of the previous materials will be the most effective as a hemostatic agent
Investigators
Eligibility Criteria
Inclusion Criteria
- •Patients with end stage liver disease that need dental extraction before liver transplant
- •Patients aged between 4 and 9 years old
- •Patients having international normalized ratio (INR) values ≤ 4 (i.e. 1-4)
Exclusion Criteria
- •Patients with allergy to sea food because chitosan- based dressing is manufactured from freeze-dried chitosan, derived from shrimp shell.
- •Patients having genetic bleeding disorders
- •Patients with renal diseases
Arms & Interventions
group 1 sterile gauze with chitosan
Chitosan-based dressing gauze after extraction in patients with end stage liver disease
Intervention: Chitosan
group 2 sterile gauze with ankaferd blood stopper
ankaferd blood stopper dressing gauze after extraction in patients with end stage liver disease
Intervention: Ankaferd Blood Stopper
group 3 sterile gauze with tranexamic acid
tranexamic acid dressing gauze after extraction in patients with end stage liver disease
Intervention: tranexamic acid
Outcomes
Primary Outcomes
To assess the hemostatic effect of chitosan-based dressing, Ankaferd and Tranexamic acid after extraction in children with end stage liver diseases
Time Frame: 30 minutes
evaluation of the previous materials which will be the most effective as a hemostatic agent by measuring blood loss after dental extraction after 30 minutes by the weight difference between the gauze preoperatively and postoperatively using fine electronic measurement weight device
Secondary Outcomes
- pain score assessment(7 days)