Prevalence of anti-thrombospondin type-1 domain-containing 7A antibodies in Japanese patients with membranous nephropathy

Not Applicable

• Conditions: Membranous nephropathy

• Registration Number: JPRN-UMIN000018079
• Lead Sponsor: Internal Medicine I, Hamamatsu University School of Medicine

Brief Summary

Enhanced granular expression of THSD7A and PLA2R was detected in 9.1% and 52.7%, respectively, of the patients with idiopathic MN. Although none of patients with secondary MN displayed enhanced granular expression of THSD7A, 5.4% of them had enhanced granular expression of PLA2R.

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2015-06-25
• Study Completion: 2015-09-22
• Last Update Posted: 17 October 2023

Recruitment & Eligibility

• Status: Complete: follow-up complete
• Sex: All
• Target Recruitment: 92

Inclusion Criteria

Not provided

Exclusion Criteria

Patients without clinical information or renal specimen

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The prevalence of enhanced granular expression of thrombospondin type-1 domain-containing7A and phospholipase A2 receptor in glomeruli of Japanese patients with idiopathic membranous nephropathy.

Secondary Outcome Measures

Name	Time	Method
Clinical characteristics of patients with enhanced granular expression of thrombospondin type-1 domain-containing7A and phospholipase A2 receptor in glomeruli. The prevalence of enhanced granular expression of IgG4 in glomeruli of Japanese patients with idiopathic membranous nephropathy.