Working memory in the presence of distraction in people with Multiple Sclerosis: underlying neural mechanisms of a novel paradigm
- Conditions
- 'MS''Multiple Sclerosis'10007951
- Registration Number
- NL-OMON53232
- Lead Sponsor
- niversiteit Leiden
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 68
Inclusion Criteria
For PwMS:
• Confirmed relapse onset MS diagnosis according to the McDonald 2017 criteria
• Expanded Disability Status Scale (EDSS) score < 7
• relapse free period >= 3 months
• unchanged therapy for >= 2 months at time of inclusion.
• Age 18-65 years
• Language: Dutch
• Pregnancy
• Inability to use the right hand
For healthy controls:
• Age 18-65 years
• Language: Dutch
• Pregnancy
• Inability to use the right hand
Exclusion Criteria
see inclusion criteria D4a.
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>The main endpoint measure of the study is the regional task-based Blood Oxygen<br /><br>Level Dependent (BOLD) response measured by fMRI during a visual and verbal WM<br /><br>task paradigm with delayed distraction and distraction at encoding compared to<br /><br>the control condition without distraction (14).</p><br>
- Secondary Outcome Measures
Name Time Method