Sedation, Temperature and Pressure After Cardiac Arrest and Resuscitation- STEPCARE Trial

Not Applicable

Recruiting

• Conditions: Neurological - Other neurological disorders; Cardiac Arrest; Cardiovascular - Coronary heart disease; Hypoxia, Brain

• Registration Number: ACTRN12623001057673
• Lead Sponsor: Region Skane

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2023-10-03
• Last Update Posted: 1 April 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 3500

Inclusion Criteria

1.Out-of-hospital cardiac arrest of non-traumatic origin
2.A minimum of 20 minutes without chest compressions (20 minutes of spontaneous circulation without the need for chest compressions is called stable return of spontaneous circulation (ROSC)”)
3.Unconsciousness defined as not being able to obey verbal commands (FOUR-score motor response of <4) or being intubated and sedated because of agitation after sustained ROSC
4.Eligible for intensive care without restrictions or limitations
5.Inclusion within 4 hours of ROSC (240 minutes from ROSC or 220 minutes from stable ROSC)

Exclusion Criteria

1.On extracorporeal membrane oxygenation (ECMO) prior to randomization
2.Pregnancy
3.Suspected or confirmed intracranial hemorrhage
4.Previously randomized in the STEPCARE trial

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Mortality -All-cause mortality assessed at 6 months after randomisation<br><br><br><br>[ 6 months after randomisation]