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临床试验/NCT05603793
NCT05603793进行中(未招募)不适用

YoUng Adolescents' behaViour, musculoskeletAl heAlth, Growth & Nutrition

Hirabai Cowasji Jehangir Medical Research Institute1 个研究点 分布在 1 个国家目标入组 1,304 人开始时间: 2022年9月13日最近更新:
适应症

试验速览

阶段
不适用
状态
进行中(未招募)
入组人数
1,304
试验地点
1
主要终点
Stunting

研究概览

简要总结

More children will survive to adulthood today than at any other point in human history, as evidenced by the proportion of live births and absolute numbers. The present generation of young people who have lived to the age of five will reach adulthood around 2030 and will be the generation of the Sustainable Development Goals (SDGs). These children's health and nutrition as they grow from 5 to 19 years will have permanent ramifications on the development of the coming generation.

The Comprehensive National Nutrition Survey was conducted between 2016 and 2018, indicating unacceptably high levels of malnutrition among Indian children and adolescents. It was discovered that one out of every five children aged 5 to 9 was stunted, indicating they were malnourished for their age. Undernourished girls are more likely to become short-statured mothers, giving birth to low-birth-weight and stunted newborns who are more prone to disease and linear growth failure. Evidence suggests that maternal short stature (less than 150 cm) predicts childhood growth failure and increases the risk of having a stunted baby by two years. The common genetic background and environmental influences that affect the mother during her early childhood and adolescence play a substantial role in the relationship between maternal stature and the linear growth of the child. This causes a cycle of undernutrition and poor growth that continues through generations and impacts the offspring's growth.

Adolescence is a key period of physical and social development when the physiological, mental, and behavioural underpinnings of long-term health are established. The development of critical bone mass is crucial during this time because it lays the foundation for preserving bone mineral integrity later in life. During adolescence, over 40% of peak bone mass is achieved. Changes in body composition are also seen during early adolescence. These physiological processes are both nutritionally sensitive and predictive of their future health. Adolescent behaviour is also linked to 33 percent of sickness and 60 percent of premature deaths in adulthood. Because adolescence is also a critical period for the development of the ability to make independent decisions, follow them through, and achieve goals- enabling healthy social networks, is critical. This includes Social and Behavioural Change Communications, which can assist early adolescents create lifetime behaviour patterns, such as good nutrition and physical exercise choices.

Investing in adolescent health and well-being pays off in three ways: during their adolescence, in their adulthood, and for their future offspring generations. Thus, young adolescence provides a "window of opportunity" for children to improve their nutritional health and outcomes.

Therefore, this cohort aims to explore the trajectories of growth (including anthropometric measures, bone mass, and muscle mass and function) among rural young adolescents and its association with intergenerational nutritional status through a longitudinal study.

A greater understanding of growth trajectories set in a longitudinal study would aid in the discovery of particular variables that influence the timing of young adolescents' growth and the factors associated with intergenerational nutritional status.

详细描述

Aims and Objectives

Aim:

This cohort aims to study the adolescent growth trajectory of girls and boys aged 8 to 10 years from rural Maharashtra. The impact of these indicators on their future offspring size will be studied by following the adolescent cohort and assessing their intergenerational nutritional status till their first offspring is 5 years old.

Objectives:

  1. To study trajectories of growth (height/ weight/ body mass index/ growth velocity) among young adolescents aged 8 to 10 years in rural areas of Maharashtra.
  2. To longitudinally study the acquisition of bone mass, muscle mass, and function in young adolescents aged 8 to 10 years in rural areas of Maharashtra.
  3. To study the association of intergenerational nutritional status among young adolescents in comparison with their parent's height and future offspring size and body composition.
  4. To strengthen Social and Behavioural Change Communication (SBCC) strategies that impact the nutritional status of young adolescents and their parents by exploring and improving their Knowledge, Attitude, and Practices.

研究设计

研究类型
Observational
观察模型
Cohort
时间视角
Prospective

入排标准

年龄范围
8 Years 至 10 Years(Child)
性别
All
接受健康志愿者

入选标准

  • 未提供

排除标准

  • 未提供

结局指标

主要结局

Stunting

时间窗: From date of enrolment, until study completion, assessed every 6 months

Stunting measured as \< -2 Height-for-age z-score

Wasting

时间窗: From date of enrolment, until study completion, assessed every 6 months

Wasting measured as \< -2 Weight-for-height z-score

次要结局

  • Body mass and composition(From date of enrolment, until study completion, assessed every 6 months)
  • Dynamic muscle function(From date of enrolment, until study completion, assessed every 1 year)
  • Bone mineral density (BMD)(From date of enrolment, until study completion, assessed every 1 year)
  • Bone volumetric density(From date of enrolment, until study completion, assessed every 1 year)
  • Bone age(From date of enrolment, until study completion, assessed every 6 months)

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Dr. Anuradha Khadilkar

Deputy director

Hirabai Cowasji Jehangir Medical Research Institute

研究点 (1)

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