NL-OMON43599
Completed
Not Applicable
A cross-sectional study to assess night-shift work related exposures and their association with markers of biological perturbation - CLOCKWORK
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Biomarkers, circadian and biological disruption markers
- Sponsor
- niversiteit Utrecht
- Enrollment
- 300
- Status
- Completed
- Last Updated
- 2 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •\- Subject is between 18 years and 65 years of age by the time of performing the screening questionnaire.
- •\- Subjects are female.
- •\- Subjects are nurse or employed in a paramedic profession.
- •\- Subjects either have not worked in a profession requiring shift work for over 5 years, just started working in night shifts (\<2 year) or worked in night\-shifts for over 5 years.
- •\- Subjects are willing to give blood, fill out the questionnaires, and wear the sensors.;For the sub\-study the same inclusion criteria apply with the exception of the last one. This criterion is replaced with:
- •\- Subjects are willing to give blood and fill out the questionnaires.
Exclusion Criteria
- •\- Subject is a smoker or ex\-smoker for less than 6 months since baseline of study inclusion. Occasional smokers that have smoked less than 100 cigarettes in their lifetime are considered non\-smokers.
- •\- Subject has a doctor diagnosed chronic disease/disorder (i.e. CVD, metabolic syndrome, diabetes).
- •\- Subject has/had cancer excluding non\-melanoma skin cancer.
- •\- Subject uses beta\-blockers, or melatonin supplementation.
- •\- Subject was pregnant in the last 6 months or is planning to become pregnant in the next 12 months.
- •\- Subject is in fertility treatment.;Exclusion criteria for the sub\-study are the same
Outcomes
Primary Outcomes
Not specified
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