NCT00197886CompletedNot Applicable
Dose of Norepinephrine and the Concentration of L-Lactate in the Rectum and Stomach in Patients With Septic Shock.
Conditions
Drugs
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Herlev Hospital
- Enrollment
- 10
- Locations
- 2
- Primary Endpoint
- L-lactate concentration in the rectum and stomach.
Study Overview
Brief Summary
Norepinephrine is a drug used to increase blood pressure in patients with life-threatening infection. However, norepinephrine may limit the bloodflow to the gut, thereby causing relative lack of oxygen to the cells. This leads to increased formation of lactic acid.
This study examines whether increasing the dose of norepinephrine leads to higher concentrations of lactic acid in the rectum and stomach in patients with life-threatening infection.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Crossover
- Primary Purpose
- Treatment
- Masking
- Single
Eligibility Criteria
- Ages
- 18 Years to — (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Septic shock
- •NE-dose > 0.1 microg/kg/min
- •CI > 3.0 l/min/m2
Exclusion Criteria
- •Age < 18, unable to obtain informed consent from relatives
- •Untreated hypertension
- •Pregnancy
- •Pathology in the rectum or stomach
- •Limitation of therapy
Outcomes
Primary Outcomes
L-lactate concentration in the rectum and stomach.
Secondary Outcomes
No secondary outcomes reported
Investigators
Study Sites (2)
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