Effects of Laser Species and Ocular Antioxidant Activity on Postoperative Inflammation and Visual Prognosis in Patients Undergoing Ophthalmic Surgery - a Comparative Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 132
- 试验地点
- 2
- 主要终点
- Change of Total Antioxidant Capacity (TAC) in aqueous humor from Baseline to one day after surgery.
研究概览
简要总结
This trial hypothesized that novel laser refractive surgery techniques (PRK, LASIK, SMILE) or laser-assisted cataract surgery (FLACAS) could suppress postoperative inflammation and improve recovery in patients by reducing oxidative stress generated by the surgical procedure. It is also intended to verify whether the new laser technology is necessary for clinical use in groups with low antioxidant activity through the detection of antioxidant activity in the eyes of patients.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 20 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •over 20 years old (included)
- •corneal refractive surgery or cataract surgery patients
排除标准
- •patients with eye infections
- •presence of severe retinal disease
- •presence of severe eye injury or severe ptosis
结局指标
主要结局
Change of Total Antioxidant Capacity (TAC) in aqueous humor from Baseline to one day after surgery.
时间窗: During the operation and one day after surgery.
Change of Ascorbic Acid (AA) in tears from Baseline to 1 month after surgery.
时间窗: Before the operation and 1 month after surgery.
Change of Total Antioxidant Capacity (TAC) in tears from Baseline to 3 months after surgery.
时间窗: Before the operation and 3 months after surgery.
Change of Total Antioxidant Capacity (TAC) in tears from Baseline to 1 week after surgery.
时间窗: Before the operation and 1 week after surgery.
Change of Total Antioxidant Capacity (TAC) in tears from Baseline to 1 month after surgery.
时间窗: Before the operation and 1 month after surgery.
Change of Total Antioxidant Capacity (TAC) in tears from Baseline to 6 months after surgery.
时间窗: Before the operation and 6 months after surgery.
Change of Ascorbic Acid (AA) in tears from Baseline to 6 months after surgery.
时间窗: Before the operation and 6 months after surgery.
Change of Ascorbic Acid (AA) in aqueous humor from Baseline to one day after surgery.
时间窗: During the operation and one day after surgery.
Change of Ascorbic Acid (AA) in tears from Baseline to 1 week after surgery.
时间窗: Before the operation and 1 week after surgery.
Change of Ascorbic Acid (AA) in tears from Baseline to 3 months after surgery.
时间窗: Before the operation and 3 months after surgery.
次要结局
- Examination of best corrected visual acuity (BCVA).(Before the operation.)
- Examination of anterior chamber depth (ACD).(Before the operation.)
- Examination of corneal curvature.(One month after surgery.)
- Examination of uncorrected visual acuity (UCVA).(One month after surgery.)
- Examination of central corneal thickness (CCT).(One month after surgery.)
- Examination of lens thickness (LT).(Before the operation.)
- Examination of intraocular pressure (IOP).(One month after surgery.)
- Examination of axial length (AXL).(Before the operation.)
- Examination of manifest refraction.(One month after surgery.)