Conditioning with volatile anesthetics in liver transplantatio

Phase 1

• Conditions: iver transplantation; MedDRA version: 12.0Level: LLTClassification code 10024716Term: Liver transplantation

• Registration Number: EUCTR2009-015890-11-BE
• Lead Sponsor: niversity Hospital Ghent

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2009-10-14
• Last Update Posted: 21 August 2017

Recruitment & Eligibility

• Status: ot Recruiting
• Sex: All
• Target Recruitment: 106

Inclusion Criteria

- Older than 18 years
- Patients undergoing liver transplantation
- Total or partial cadaveric liver transplantation

Are the trial subjects under 18? no
Number of subjects for this age range:
F.1.2 Adults (18-64 years) no
F.1.2.1 Number of subjects for this age range
F.1.3 Elderly (>=65 years) no
F.1.3.1 Number of subjects for this age range

Exclusion Criteria

- Patients unable to understand the Flemish or Dutch language
- Patients with known or suspected allergy to propofol, soja or egg
- Patients with norepinephrine infusion above 15 microg/min
- Intensive care patients with severe impairment of renal or pulmonary function (e.g. dialysis, hemofiltration, FiO2>0.5)

Study & Design

• Study Type: Interventional clinical trial of medicinal product
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Main Objective: Hypothesis<br>Sevoflurane conditioning, applied as pre- and postconditioning in liver transplant recipients, attenuate ischemic-reperfusion injury compared with the i.v. propofol anesthesia. <br>;Secondary Objective: Complication score (surgical complications);Primary end point(s): Postoperative peak of the transaminase (AST).