Stem cells as an alternative therapy to liver transplantation. A combined experimental study and clinical trial.

Not Applicable

• Conditions: K74; Fibrosis and cirrhosis of liver

• Registration Number: DRKS00016531
• Lead Sponsor: Faculty of medicine-Tanta University

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Completion: 2018-09-01
• Study Start: 2019-01-17
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 18

Inclusion Criteria

All male or female patients aged from 40 to 60 years with evidence of liver decompensation as ascites, low prothrombin time less than 50%, low serum albumin less than 2.5 g/dl, past history of hepatic encephalopathy were included in the study

Exclusion Criteria

Pregnant or lactating females, patients with recent gastrointestinal bleeding (one month), hepatocellular carcinoma, spontaneous bacterial peritonitis, an evidence of human immunodeficiency virus, any life threatening infection, having history of hypersensitivity to G-CSF and those included in any other clinical trials within the previous month were excluded.

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
What?<br>- Improvement of clinical, biochemical and radiological characteristics<br>How?<br>-Both groups were subjected to: complete history taking, clinical examination (ascites, jaundice, and Lower Limb edema), Abdominal U/S , and laboratory investigations: serum bilirubin, ALT, AST, albumin, INR, with estimation of the degree of ascites, encephalopathy and Child-Pugh Class. <br>When? <br>- All of these clinical, laboratory and radiological investigations were performed before treatment (baseline) and after 1, 3 and 6 months of treatment (follow up).