Additive effect of Dashmul Yog Basti along with Kumkum siddha Ghrita Nasya in Ardhavabhedak w.s.r. to Migraine

Recruiting

Conditions: Periodic headache syndromes in child or adult,

Registration Number: CTRI/2019/12/022344

Lead Sponsor: HOD Shalakyatantra Dept R A Podar Medical Ayurvedic College

Brief Summary: Headache is commonest problemexperienced by humansin day to day life. Migraineis presented with symptoms like paroxysmal unilateralheadache with throbbing and pulsating type of pain. Somepatients may experience nausea (with or without vomiting), photophobia, phonophobia, with or withoutaura.

Accordingto international headache society migraine is commonest neurovascular headache which constitutes 16% of primaryheadache and affects10%-20% of general population. WHO ranks migraineamong the worldâ€™smost disabling medicalillness.During adolescence migraine becomes more common amongfemales and it will persistfor lifetime.

The word â€œMIGRAINEâ€ is derived from Greek word â€œHemi craniaâ€which means â€œhalf ofheadâ€ because thepain of migraineoften occurs on one sideof head. Sometime it spreads to entirehead. The termmigraine mainly refersto a syndrome of vascular spasm of cranial blood vessels and it is usuallyan episodic headache.

In*Ayurvedic Samhitas*, migraine is found to be similarto one of the Shirorogas named as *Ardhavbhedak.* Which is characterized by A*rdhshir vedana* means unilateral headache.There are some other symptomsof *Ardhavbhedak* can also correlate with migraine, such as*Toda*, *Bheda*, *Bhrama* means *pulsatind* andthrobbing type of pain, vertigo.Ardhavbhedak is one of the *Shirorogas* explained in classical *ayurvedic* texts.According to *acharya Charaka*,*vata dosha* eitheralone or along with *Kapha* seizes theone half of head and causes *Ativedana* in sides of *Manya(neck), Bhru(eyebrow), Shankha(temporal region),Karna(ear), Akshi(eyes), lalatardh(one sideof forehead)* andif the symptomsbecomes aggravated it mayaffects the functionof *Netra* and *Shrotra*.

Theproper history takingof patient playsimportant role in diagnosis of migraine. The line of treatment of modern scienceincludes acute rescue,life style changes,alternative remedies and prophylactic drugs.The Triptans have improved acute treatment but overuseof acute rescuemedication can causeschronic daily headache.

Need of studyModern medications gives instantrelief from painand other symptomof migraine but underlying pathology goes on and progressively worsen the condition. There are some drawbacks of these medicines likesedation, weight gain, drug dependency and recurrence. Therefore there is need of alternative therapy for migrainepain management.

According to *Ayurveda* pain is present dueto *Vata dushti*.So there is need of suchtherapy which can reduces the *Vata dushti*. Acharyasaid that nasal route is the nearest route for treatment of *Shirorogas*and *Nasya Karma* issignificant for all *Urdhwajatrugat rogas.* According to *KaiyadevaNighantu Kumkum* has*Tridoshhar* properties and also effective on *shirorogas*. Ayurveda considered *Basti*is one of the best treatment for *vatadushti*and it is main *upakrama for vata*.*Acharya Charaka* has given specific treatmen on *Shirorogas*which includes *Nasya and Basti*. Drugsincluded in *Dashmul* are specifically used in *Vata dushtigatrogas*.

Hence I havetaken this subject for study:

**â€œA randomized clinical comparative studyto evaluate the effect of *DashmulYog Basti* followed *by KumkumSiddha Ghrita Nasya*And *Kumkum Siddha GhritaNasya* in the** **management of *Ardhavbhedak* withspecial reference to Migraine,â€**

Detailed Description: Not available

Recruitment & Eligibility

Status: Open to Recruitment

Sex: All

Target Recruitment: 60

Inclusion Criteria

1.Individuals of either sex 2.Age- 18 years to 50 years 3.H/O- headache more than 6 months 4.Frequency of episodes- 3to5 episodes in one year 5.Patients having symptoms of Ardhavbhedak i.e Ardhashirovedana, Tod ,Bhed, shool, Prakash asahatva manya-bhru-akshi-karna vedana 6.Patient willing to take therapy and to give written consent.
7.Patient of controlled diabetes mellitus( fasting 70-110mg/dl Post prandial-110-140mg/dl).

Exclusion Criteria

1.Pregnant and lactating women 2.Patient suffering from major illnesses e.g Tuberculosis / Hypertension/ cardiovascular diseases/epilepsy/malignancy 3.Having H/O-head injury or trauma 4.HIV and HBSAg positive patients 5.Patient under psychiatric medication.
6.Patients having bleeding disorders.
7.Other types of headache.
8.Referred pain in one half of head due to diseases of eye ,nose,throat, ear.
9.Patient with complicated migraine, status migrainous, othalmic migraine, hemiplegic migraine etc.

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To evaluate the combined effect of Dashmul Yog Basti followed by Kumkum Siddha Ghrita Nasya in the management of Ardhavbhedak with special reference to Migraine.	To evaluate the combined effect of Dashmul Yog Basti followed by Kumkum Siddha Ghrita Nasya in the management of Ardhavbhedak with special reference to Migraine by the end of 40 days

Secondary Outcome Measures

Name	Time	Method
To compare the efficacy of Dashmul Yog Basti followed by Kumkum Siddha Ghrita Nasya and Kumkum Siddha Ghrita Nasya in the management of Ardhavbhedak with special reference to Migraine..	To compare the efficacy of Dashmul Yog Basti followed by Kumkum Siddha Ghrita Nasya and Kumkum Siddha Ghrita Nasya in the management of headache , aura & other symptoms seen in Ardhavbhedak by the end of 40 days.
To evaluate the efficacy of Kumkum Siddha Ghrita Nasya in the management of	Ardhavbhedak with special reference to Migraine.

Trial Locations

Locations (1): R.A.Podar Med(Ayu) College & M.A.Podar Hospital
🇮🇳
Mumbai, MAHARASHTRA, India
R.A.Podar Med(Ayu) College & M.A.Podar Hospital
🇮🇳Mumbai, MAHARASHTRA, India
Dr Amrut Salunke
Principal investigator
9819139017
dramrut16@gmail.com