Fibrinolytic parameters in women with heavy menstrual bleeding
- Conditions
- Heavy menstrual bleeding / Hevig menstrueel bloedverliesMenorrhagia / menorrhagieMenstrual cycle / menstruele cyclusFibrinolysis / fibrinolyseClot lysis time / Clot lysis tijd
- Registration Number
- NL-OMON22702
- Lead Sponsor
- niversity Medical Centre GroningenDepartment of HematologyProf. J.C. Kluin-NelemansHanzeplein 19713 GZ Groningen
- Brief Summary
Our previous research on this topic is published:<br> Titel: No increased fibrinolysis in women with heavy menstrual bleeding. <br> Authors: Wiewel-Verschueren S, Knol HM, Lisman T, Bogchelman DH, Kluin-Nelemans JC, van der Zee AG, Mulder AB, Meijer K.<br> Published: J Thromb Haemost. 2014 Sep;12(9):1488-93.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 20
Inclusion Criteria
Inclusion criteria for patients:
- Patients with regular heavy menstrual bleeding (=menorrhagia).
Exclusion Criteria
Exclusion criteria for patients:
- Patients with postmenopausal, postcoital or intermenstrual bleeding
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method - Investigate the cyclic variation in clot lysis time in women with HMB in comparison to controls.
- Secondary Outcome Measures
Name Time Method - Investigate the cyclic variation in TAFI, PAI-1, tPA, PI, thrombin generation, fibrin clot permeation and confocal microscopy analysis of fibrin clots in women with HMB in comparison to controls. <br /><br>- Investigate the ovulatory menstrual cycle by measuring progestagen.