A dose response study of the effects of increased fruit and vegetables intake on vascular functio

Completed

• Conditions: Elevated blood pressure; Circulatory System

• Registration Number: ISRCTN50011192
• Lead Sponsor: Food Standards Agency (UK)

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2005-09-09
• Last Update Posted: 13 January 2015

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 48

Inclusion Criteria

Subjects will be male or female, non-smoking and aged between 22-65 years. A principal aim is to identify and recruit subjects with moderate elevation of Blood Pressure (BP). Eligible subjects will have diastolic more than 80 mmHg and less than 100 mmHg and a systolic BP of less than 160 mmHg.

Exclusion Criteria

1. Current smokers
2. A reported history of myocardial infarction or cancer
3. Diabetes mellitus (fasting plasma glucose more than 7 mmol/l)
4. Recent use of oral hypolipidaemic therapy, systemic corticosteroids, androgens, phenytoin, erythromycin or thyroid hormones
5. Current use of antihypertensive medication
6. Those receiving drugs for regulating haemostasis but excluding aspirin or who have been exposed to any investigational agent within 30 days of the study
7. Chronic coronary, renal or bowel disease or history of cholestatic liver disease or pancreatitis
8. Presence of gastrointestinal disorder or use of a drug, which is likely to alter gastrointestinal motility or nutrient absorption
9. History of substance abuse or alcoholism
10. Currently pregnant, planning pregnancy, or having had a baby in the last 12 months
11. Allergy or intolerance to intervention foods
12. Unwilling to follow the protocol and/or give informed consent
13. Unwilling to refrain from use of dietary supplements
14. Weight loss at more than 3 kg in preceding two months
15. Alcohol intake not exceeding a moderate intake of (less than 24 - 36 g/day)
16. Body Mass Index more than 20 and less than 35 kg/m^2
17. Subjects with a blood pressure and other risk factors that make them eligible for drug treatment of raised blood pressure according to the UK guidelines of the British Hypertension Society

Study & Design

• Study Type: Interventional
• Study Design: Not specified