Effect of HEPA Air Filters on Subclinical Markers of Cardiovascular Health

Not Applicable

Completed

• Conditions: Endothelial Function; Oxidative Stress; Systemic Inflammation
• Interventions: Device: HEPA filter

• Registration Number: NCT01256957
• Lead Sponsor: Simon Fraser University

Brief Summary

The purpose of this study is to evaluate the ability of portable high efficiency particle air (HEPA) filters to reduce exposures to PM2.5 and woodsmoke air pollution indoors and to improve subclinical indicators of microvascular function, systemic inflammation, and oxidative stress among healthy adult participants.

Detailed Description

The investigators will use portable HEPA filters in a single-blind randomized crossover design. Each participant's home will be monitored for two consecutive seven-day periods, during which time two HEPA units (one in the bedroom and one in the main living room) will be operated indoors. During one 7-day period the HEPA filters will be operated normally, and during the other period the HEPA unit will be operated without the internal filter in place (i.e., "placebo filtration"), thus blinding participants to the filters' status. The order of filtration or non-filtration will be random. At the end of each 7-day period microvascular function will be assessed, blood will be collected for assessment of systemic inflammatory markers, and urine will be collected for assessment of oxidative stress markers.

Study Timeline

• Study Start: 2008-11
• Primary Completion: 2009-04
• Study Completion: 2009-04
• Status Verified: 2010-12
• Study First Submitted: 2010-12-08
• Study First Submitted QC: 2010-12-08
• Study First Posted: 2010-12-09
• Last Update Submitted: 2016-12-01
• Last Update Posted: 2016-12-05

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 56

Inclusion Criteria

• 19 years or older
• Non-smoking household
• Lives in study region (Smithers or Telkwa British Columbia)

Exclusion Criteria

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Indoor air HEPA filtration	HEPA filter	HEPA filters operating in the participant's bedroom and living room.

Primary Outcome Measures

Name	Time	Method
Reactive hyperemia index	After 1 week of air filtration

Secondary Outcome Measures

Name	Time	Method
C-reactive protein	After 1 week of filtration

Trial Locations

Locations (1)

Simon Fraser University; 🇨🇦 Burnaby, British Columbia, Canada