Differing Levels of Positive Anti-Neutrophil Cytoplasm Antibody (ANCA) Test and Their Correlation With Vasculitis or Malignancy or Chronic Inflammation

• Conditions: Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
• Interventions: Other: Follow-up

• Registration Number: NCT02180126
• Lead Sponsor: Hillel Yaffe Medical Center

Brief Summary

A positive Anti-Neutrophil Cytoplasm Antibody (ANCA) test administered to patients with a high probability for vasculitis has high sensitivity and specificity for vasculitis. A positive ANCA test result in those patients who do not have a high probability for vasculitis requires extensive follow-up because those patients eventually present with malignancy or other inflammatory diseases. The investigators wish to investigate the correlation between the differing levels of positive ANCA tests and their relationship to vasculitis, malignancy and inflammatory diseases.

Detailed Description

Not available

Study Timeline

• Status Verified: 2014-07
• Study First Submitted: 2014-07-01
• Study First Submitted QC: 2014-07-01
• Last Update Submitted: 2014-07-01
• Study First Posted: 2014-07-02
• Last Update Posted: 2014-07-02
• Study Start: 2014-08
• Primary Completion: 2015-01
• Study Completion: 2015-01

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 160

Inclusion Criteria

• Patients with borderline positive ANCA test results

Exclusion Criteria

• Pregnant

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Positive ANCA	Follow-up	Patients with borderline positive ANCA results.

Primary Outcome Measures

Name	Time	Method
Borderline Positive ANCA	Two weeks	Borderline positive ANCA results of 12-19 U/ml is indication of possible malignancy or inflammatory diseases

Trial Locations

Locations (1)

Hillel Yaffe Medical Center; 🇮🇱 Hadera, Israel