Impact of Serum Progesterone Levels on Embryo Transfer Day on Clinical Pregnancy in Frozen-thawed Embryo Transfer Cycles Using Hormone Replacement Therapy: a Prospective Observational Study
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 370
- 试验地点
- 1
- 主要终点
- Clinical pregnancy rate (CPR)
研究概览
简要总结
Hypotheses:
We hypothesize that serum progesterone levels on the day of embryo transfer in HRT-FET cycles are positively associated with clinical pregnancy rates.
Aims:
To evaluate the relationship between serum progesterone levels on embryo transfer day and clinical pregnancy outcomes in frozen-thawed embryo transfer cycles using hormone replacement therapy (HRT).
Primary outcome:
To compare the incidence of clinical pregnancy outcome in those infertility patients undergoing frozen embryo transfer with caterized Progesterone level on the day of embryo transfer
Secondary outcomes:
Biochemical pregnancy rate. Implantation rate. Early pregnancy loss rate. Ectopic pregnancy rate.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 42 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Patients undergoing FET cycles
- •Infertility patients aged >18 years old and < 42 years old
- •BMI < 30 kg/m2
- •Transfer of at least one good-quality embryo.
排除标准
- •Severe endocrine disorders (e.g., thyroid dysfunction, premature ovarian failure).
- •Severe uterine factors without treatment (severe endometriosis, extensive or subendometrial fibroid, uterine adherent, endometrial polyps)
结局指标
主要结局
Clinical pregnancy rate (CPR)
时间窗: 6 weeks of gestation and ultrasound scanning will be performed to confirm at least one gestational sac around 1 to 3 months after FET
Rate of clinical pregnancy outcome in subjects undergoing FET
次要结局
- Biochemical pregnancy rate(Up to 12 weeks)
- Implantation rate(Up to 12 weeks)
- Early pregnancy loss rate(Up to 12 weeks)
- Ectopic pregnancy rate(Up to 12 weeks)
研究者
Chung Pui Wah Jacqueline
Associate Professor
Chinese University of Hong Kong