Efficacy of pamidronate for adult osteogenesis imperfecta: uncontrolled study.
Not Applicable
- Conditions
- Osteogenesis imperfecta
- Registration Number
- JPRN-UMIN000031290
- Lead Sponsor
- Kobe University Hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up continuing
- Sex
- All
- Target Recruitment
- 10
Inclusion Criteria
Not provided
Exclusion Criteria
1) eGFR less than 30 2) patients who have severe renal or hepatic failure. 3) Patients who have allergy against the drug. 4) Patients who are pregnant. 5) Patients who participated to another clinical study within 4 months. 6) Patients who are very poor condition. 7) Patients who have cardiovascular disease (including QTc >500msec). 8) Patinets who are diagnosed as inappropriate for this study including the results of screening test results.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The change from baseline of lumbar 1-4 bone mineral density at weak 68.
- Secondary Outcome Measures
Name Time Method The change of both femoral neck and radius bone mineral density. Improvement of bone pain. Improvement of QOL. Rate of adverse event.