Study of Alloknesia in Atopic Dermatitis

Not yet recruiting

• Conditions: Atopic Dermatosis; Alloknesie

• Registration Number: NCT06923202
• Lead Sponsor: University Hospital, Brest

Brief Summary

Alloknesia is defined as pruritus (= itching) triggered by light mechanical stimuli, which are responsible for the perception of light touch under physiological conditions, but which are perceived as pruritic under pathological conditions. Alloknesia occurs mainly in the context of chronic pruritus. Consequently, patients suffering from chronic pruritus frequently perceive light touch sensations as pruritic, which can be particularly unpleasant and alter human interactions and quality of life on a daily basis. However, the epidemiology and burden of alloknesia have never been studied, whatever the cause of chronic pruritus.

Atopic dermatitis is one of the main diseases causing chronic itching, and patients frequently complain of alloknesia.

In this study, we aim to investigate the frequency of alloknesia in patients with atopic dermatitis and to measure the consequences of alloknesia in these patients.

Detailed Description

Not available

Study Timeline

• Status Verified: 2025-04
• Study First Submitted: 2025-04-04
• Study First Submitted QC: 2025-04-04
• Last Update Submitted: 2025-04-04
• Study First Posted: 2025-04-11
• Last Update Posted: 2025-04-11
• Study Start: 2025-04-30
• Primary Completion: 2026-05-01
• Study Completion: 2026-05-01

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 160

Inclusion Criteria

• Age ≥18 years
• No opposition from the patient
• Diagnosis of atopic dermatitis more than 6 months old

Exclusion Criteria

• Patients who are physically or mentally unable to complete the questionnaires.
• Patients on systemic treatment for 1 month or more
• Refusal to participate
• Patients under legal protection (guardianship, curatorship)
• Patients under court protection

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Alloknesia diagnostic questionnaire	Day of inclusion. If the patient completes the questionnaires at home, they will be brought back by the patient at their next medical consultation.	The questionnaire consists of a single question: 'Can the touch of your skin by clothing, air movements or the light touch of an object or another person trigger itching?

Secondary Outcome Measures

Name	Time	Method
DLQI (Dermatology Life Quality Index) questionnaire	Day of inclusion. If the patient completes the questionnaires at home, they will be brought back by the patient at their next medical consultation.	Skin-related quality of life
HADS (Hospital Anxiety and Depression Scale) questionnaire	Day of inclusion. If the patient completes the questionnaires at home, they will be brought back by the patient at their next medical consultation.	The HAD scale is an instrument for screening for anxiety and depressive disorders.
Stigmatisation : PUSH-D questionnaire	Day of inclusion. If the patient completes the questionnaires at home, they will be brought back by the patient at their next medical consultation.	PUSH-D allows a comprehensive view of the degree of stigmatization in visible skin disorders.
Stress perçu : PSS (Perceived Stress Scale)	Day of inclusion. If the patient completes the questionnaires at home, they will be brought back by the patient at their next medical consultation.	The PSS (Perceived Stress Scale) is a scale for measuring perceived stress.
Insomnia: Epworth questionnaire	Day of inclusion. If the patient completes the questionnaires at home, they will be brought back by the patient at their next medical consultation.	The Epworth Test is a self-administered questionnaire that assesses subjective sleepiness and fatigue.
ISS (Sexual Satisfaction Index) questionnaire	Day of inclusion. If the patient completes the questionnaires at home, they will be brought back by the patient at their next medical consultation.	Satisfaction with sexual relations
WI-NRS scale	Day of inclusion. If the patient completes the questionnaires at home, they will be brought back by the patient at their next medical consultation.	Digital pruritus scale, measuring the worst daily itching intensity
ItchyQoL questionnaire	Day of inclusion. If the patient completes the questionnaires at home, they will be brought back by the patient at their next medical consultation.	Itch-related quality of life