SEQUOIA : Cognitive Processing of Natural Sequences in Humans and Artificial Intelligence (AI)
Trial Snapshot
- Phase
- Not Applicable
- Status
- Not yet recruiting
- Sponsor
- Institut Pasteur
- Enrollment
- 700
- Primary Endpoint
- Correlation between neural recordings and IA models
Study Overview
Brief Summary
The goal of this study is to identify electrical patterns in the cortex that enable the generation of predictions in natural auditory sequences such as speech and music.
Between 500 and 700 participants in total (250 to 350 normally hearing participants (including 60 to 120 participants from West Africa and 60 to 120 participants from Western Europe) and 250 to 350 participants with hearing loss (no restrictions on origin)).
Participants will listen to naturally recorded music and speech via headphones. They will be asked to rate these stimuli on a scale from 0 to 10 in terms of pleasure and comprehension, using a keyboard and mouse or voice input. Additionally, they will be required to sing or produce novel/improvised vocal responses using high-fidelity microphones. This entire procedure will be conducted under electroencephalography (EEG) to record neuronal responses throughout the process.
Study Design
- Study Type
- Observational
- Observational Model
- Case Control
- Time Perspective
- Prospective
Eligibility Criteria
- Ages
- 18 Years to 85 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •For hearing participants:
- •Average pure-tone thresholds ≤ 20 dB HL
- •For participants with hearing loss:
- •Average pure-tone thresholds > 20 dB HL
- •For participants of West African origin:
- •Average pure-tone thresholds ≤ 20 dB HL
- •Declare that both parents are of West African origin, either by their own birth or by the birth of both of their parents.
Exclusion Criteria
- •No known neurological or audiological disorders
- •Participants under legal guardianship (tutelle, curatelle)
- •Participants deprived of legal liberty by judicial or administrative decision
Outcomes
Primary Outcomes
Correlation between neural recordings and IA models
Time Frame: Day 1
To identify electrical patterns in cortex which generates predictions in natural auditory sequences (such as speak and music).
Secondary Outcomes
- Compare predictions generated across different cultural contexts(Day 1)
- Compare predictions for identical stimuli across repeated sessions to establish a link between processing and successful memorization/retention.(From enrollement to visit 2 (10 days))
- Compare predictions generated between hearing individuals and those with hearing impairments.(Day 2)
- Correlate predictive measures with responses to autism symptom questionnaires across the various experiments.(Day 1)