Celecoxib for Reducing Morphine Requirement After Thyroid Surgery: A Randomized Controlled Trial
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 入组人数
- 80
- 试验地点
- 1
- 主要终点
- The patients' total amount of morphine requirement in the first 24 hour.
研究概览
简要总结
The purpose of this study is to determine whether celecoxib is effective in the treatment postoperative pain after thyroidectomy.
The research hypothesis:
There is a difference in postoperative morphine consumption in the first 24 hours after thyroidectomy between patients who received celecoxib or placebo.
详细描述
Postoperative pain has been concerned in the past few years by both the anesthesiologists ans the surgeons. COX2-inhibitors have played an important roles in postoperative pain with minimal side effects.
Comparison(s): There is a difference in postoperative morphine consumption in the first 24 hours after thyroidectomy between patients who received celecoxib and placebo.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patient ASA physical status I-III.
- •Scheduled for an elective thyroidectomy.
- •Body weight > or = 40kg
- •Can operate a patient-controlled analgesia (PCA) device.
排除标准
- •History of asthma, acute rhinitis, nasal polyps, angioneurotic edema or urticaria following the administration of aspirin or other NSAIDs.
- •Known hypersensitivity to morphine or sulfonamides.
- •History of hepatic dysfunction.
- •Creatinine clearance < 30ml/min.
- •History of bleeding tendency.
- •History of gastrointestinal bleeding or active peptic ulcer.
- •Known case of inflammatory bowel disease.
- •Patient with severe heart failure.
研究组 & 干预措施
2
- placebo
- celecoxib
干预措施: celecoxib (Drug)
结局指标
主要结局
The patients' total amount of morphine requirement in the first 24 hour.
时间窗: 24 hour
次要结局
未报告次要终点