Assessment of acute gastrointestinal injury (AGI) by point of care ultrasound (POCUS) to predict feeding intolerance in adult critically ill patients- a prospective observational study
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 172
- 试验地点
- 1
- 主要终点
- To determine the predictive ability of POCUS before initiation of enteral nutrition in adult critically ill patients with feeding intolerance
研究概览
简要总结
Patients with acute gastrointestinal injury (AGI) have higher mortality than those without AGI. Feeding intolerance (FI) is present in 35-40% of critically ill patients on enteral nutrition. FI is an independent predictor of mortality. Assessment of AGI is usually done by clinical symptoms which lack objectivity. Ultrasound based AGI scores have been developed recently but most of them are complex to use and moreover, none of them are validated in clinical studies. In this study, we are planning to develop a rapid and reliable mode of assessment of AGI with the help of POCUS before initiation of enteral nutrition to predict feeding intolerance in critically ill adult patients.
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18.00 Year(s) 至 80.00 Year(s)（—）
- 性别
- All
入选标准
- •1.Patients aged more than 18 years of age on mechanical ventilation (invasive and non-invasive) 2.ICU stay more than 72 hours 3.Patients planned for enteral nutrition and feeding protocol as per institutional practice.
排除标准
- •Patients with gastrointestinal surgery
- •Patients with abdominal trauma
- •Patients with terminal illness and advanced cancer
- •Patients with pre-existing abdominal pathologies
- •ICU stay less than 72 hours.
结局指标
主要结局
To determine the predictive ability of POCUS before initiation of enteral nutrition in adult critically ill patients with feeding intolerance
时间窗: POCUS will be done at baseline (before EN), 48 hours after enteral nutrition initiation
次要结局
- 1. To determine the 30-day mortality in patients with feeding intolerance(2. To determine the duration of mechanical ventilation, requirement of vasopressors and length of ICU stay in patients with feeding intolerance)