Glycine Supplementation Improves Cognitive Performance in Mexican Older Adults
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 59
- 试验地点
- 1
研究概览
简要总结
The purpose of this study was to evaluate the effects of daily glycine supplementation on metabolic health and cognitive performance in older adults. Over a period of six months, participants received 1,000 mg of glycine per day to determine if this amino acid could improve markers of insulin resistance, glucose metabolism, and cognitive functions such as memory and executive tasks.
The research aimed to identify whether this nutritional intervention provides a safe and effective strategy to support healthy aging, focusing on the link between metabolic balance and brain health in the elderly population.
详细描述
A 6-month longitudinal study was conducted, featuring a glycine supplementation phase followed by a dietary maintenance period. Cognitive assessments and serum BDNF levels were monitored at baseline, 3 months (T3), and 6 months (T6). Which included the evaluation of fasting glucose, insulin levels, insulin resistance indices, and specific metabolic biomarkers. Concurrently, cognitive functions were evaluated utilizing standardized neuropsychological instruments to measure changes in memory, attention, and executive function. Linear Mixed-Effects Models (LMM) were used to analyze temporal trajectories.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Supportive Care
- 盲法
- None
入排标准
- 年龄范围
- 60 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Individuals across all nutritional statuses according to Body Mass Index (BMI), under-weight, normal weight, overweight, and obesity
排除标准
- •Clinically relevant comorbidities (requiring patient hospitalization or a diagnosis of any infectious/contagious disease), consumption of polyphenol-based supplements or herbal blends within the two weeks prior to the study and mental incapacity, lack of willingness, or language barriers that prevent adequate understanding or co-operation
研究者
Brenda Sarahí Beristain Lujano
Principal Investigator and Doctoral Researcher
Escuela Superior de Medicina