Comparison of efficacy of valproate and oxcarbazepine in children with self-limited epilepsy with centrotemporal spikes: a randomized control trial VO-SELECT trial

This RCT will compare two commonly used anti-epileptic drugs valproate and oxcarbazepine in children with self-limited epilepsy with centro-temporal spikes, aged 3-14 years. This is a very common type of epilepsy in children. In this RCT, we will randomize 114 eligible cases of newly diagnosed self limited epilepsy with centro-temporal spikes to either oxcarbazepine or valproate group. While oxcarbazepine group will receive the drug at 15 mg/kg/day in two divided doses daily for 12 weeks, the participants in valproate group will receive the drug at 20 mg/kg/day in two divided doses for 12 weeks. We will compare the proportion of participants who remain seizure free at 12 weeks in both groups and also number of participants with any adverse effect in both groups.