Impact of GH Measurements on GHD Diagnosis

Completed

• Conditions: Growth Hormone Deficiency

• Registration Number: NCT04508673
• Lead Sponsor: University Hospital, Montpellier

Brief Summary

Human growth hormone (hGH) provocation test is an essential tool to assess growth hormone deficiency in children and young adults. It is important to have a robust and reliable method to determine the hGH peak of stimulation. This work aimed to compare three common automated immunoassays for hGH measurements and to assess whether there are still result-related differences influencing clinical decision.

Detailed Description

The investigators analysed GH provocative test of 41 young patients (median age: 12 years) from Pediatric Department of Montpellier Hospital, (26 boys and 15 girls), admitted for follow-up or for suspicion of growth hormone deficiency. Serum GH of peak concentrations were compared using three automated immunoanalyses : COBAS 8000 e602 (ROCHE Diagnostics), IDS-iSYS (IDS immunodiagnostic systems) and Liaison XL (Diasorin S.A.).

Study Timeline

• Study Start: 2019-04-01
• Primary Completion: 2019-11-01
• Study Completion: 2019-11-25
• Status Verified: 2020-08
• Study First Submitted: 2020-08-07
• Study First Submitted QC: 2020-08-07
• Study First Posted: 2020-08-11
• Last Update Submitted: 2020-08-12
• Last Update Posted: 2020-08-17

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 41

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Comparative study of human growth hormone measurements	1 day	Comparative study of human growth hormone measurements by using three different automated immunoassays

Secondary Outcome Measures

Name	Time	Method
Stratification of patients based on GH peak secretion	1 day	Stratification of patients based on GH peak secretion

Trial Locations

Locations (1)

Uhmontpellier; 🇫🇷 Montpellier, France