Creatine kinase and hypertensio
- Conditions
- high blood pressurehypertension10057166
- Registration Number
- NL-OMON34574
- Lead Sponsor
- Academisch Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 80
Inclusion Criteria
Ambulatory adult subjects aged 18-50 years, normotensives and untreated hypertensives (Stage 1 primary hypertension SBP/DBP 140-159/90-99), with high/low-normal CK, matched for body mass index.
Exclusion Criteria
BMI>/= 30 kg/m2, CK not in the lowest or highest population tertile; glucose, lipid spectrum, thyroid, kidney, or liver abnormalities, treated, stage 2 (SBP *160 or DBP *100), or secondary hypertension, (history of) cardiovascular disease including TIA and stroke; CK-increasing drugs including statins; neuromuscular or endocrine disorders; vasculitis; HIV infection; infectious hepatitis; bleeding disorders.
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Difference in salt excretion with low vs high serum CK.</p><br>
- Secondary Outcome Measures
Name Time Method <p>Difference in vascular contractility with low vs high serum CK.</p><br>