Seaweed-derived Rhamnan Sulfate and Vascular Function

Not Applicable

Recruiting

• Conditions: Cardiovascular Diseases
• Interventions: Dietary Supplement: Rhamnan sulfate

• Registration Number: NCT05651230
• Lead Sponsor: University of Texas at Austin

Brief Summary

The primary aim of the proposed investigation is to examine the hypothesis that a relatively short period of rhamnan sulfate supplementation would improve key markers of vascular dysfunction in middle-aged and older adults with at least one risk factors for cardiovascular disease.

Detailed Description

Not available

Basic Information
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Recruitment & Eligibility
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Study & Design
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Trial Locations

Study Timeline

• Study First Submitted: 2022-11-28
• Study First Submitted QC: 2022-12-06
• Study First Posted: 2022-12-14
• Study Start: 2023-04-01
• Status Verified: 2023-05
• Last Update Submitted: 2023-05-08
• Last Update Posted: 2023-05-10
• Primary Completion: 2024-05-01
• Study Completion: 2024-05-01

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 15

Inclusion Criteria

• at least one risk factor for cardiovascular disease (e.g., dyslipidemia, hypertension, obesity, impaired fasting glucose)
• a BMI of <40 kg/m2

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Exclusion Criteria

• gastrointestinal disorders and/or renal disease
• pregnancy or lactation
• strenuous physical activity (>3 times/week)
• alcohol abuse

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Placebo	Rhamnan sulfate	The subjects will take placebo (Konan Chemical Manufacturing Co. LTD, Mie, Japan: 540 mg/day) orally three time daily at each meal time.
Rhamnan sulfate	Rhamnan sulfate	The subjects will take rhamnan sulfate (Rhamnox100, Konan Chemical Manufacturing Co. LTD, Mie, Japan: 540 mg/day) orally three time daily at each meal time.

Primary Outcome Measures

Name	Time	Method
Vascular function	After the 3-week intervention	Endothelium-dependent vasodilation as assessed by flow-mediated dilation

Trial Locations

Locations (1)

Cardiovascular Aging Research Lab at UT Austin; 🇺🇸 Austin, Texas, United States