Effectiveness Study of New Generation Bednets in the Context of Conventional Insecticide Resistance in the Democratic Republic of the Congo
- Conditions
- Insecticide Resistance
- Interventions
- Drug: synergistic combination of insecticidesDrug: Pyrethroids
- Registration Number
- NCT03289663
- Lead Sponsor
- Université de Lubumbashi
- Brief Summary
Despite the mass distribution of LLINs (long-lasting insecticidal nets) as a Malaria control strategy, populations are still continuously exposed to a high frequency of malarial inoculation in some countries. The situation can be explained by a swift increase in the resistance of Anopheles to common insecticides. To preserve the gains of insecticides and improve their effectiveness, a new generation of bednets treated with piperonyl butoxide combination insectides have emerged.But more evidence is needed to plead for scale up of their usage. The lack of information relating to the additional impact of that combination on the transmission of Malaria, its relative efficacy in real-life setting and its safety in users are the rationale for more investigation.This will be a randomized controlled study on a dynamic cohort of households with 1680, 0-10 years-old subjects in 30 villages will be recruited to compute the effectiveness of this new tool.
The findings will be useful information for decision-making by national malaria control programs, their partners, the international community and the bednet manufacturers with regard to the effectiveness of the new combination of insecticides in real-life context. The results will also enable a better design of the tool in the future and a broader understanding of long-term dynamics for sustainability, as well as identification of some factors with negative impacts on the benefits of the strategy.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 1680
Not provided
Not provided
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Experimental synergistic combination of insecticides The arm will receive bednets treated with new generation of insecticides (synergistic combination of insecticides) Control Pyrethroids The arm will receive bednets treated with conventional insecticide (Pyrethroid)
- Primary Outcome Measures
Name Time Method Sporozoite rate Anopheles mosquitoes will be captured every 3 months during 1 year Sporozoite detection by ELISA to determine infectivity of anopheles
Incidence rate of laboratory confirmed clinical cases of Malaria Participants will be actively followed up for 12 months. And any suspected case of clinical Malaria will immediately lead to microscopy and RDT for confirmation Microscopy to confirm the diagnosis of Malaria
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Hôpital Général de Référence Saint Luc
🇨🇩Kisantu, Kongo-Central, Congo, The Democratic Republic of the