Study of Breath-holding as a Means to Reduce Tumor Motion From Breathing

Not Applicable

Terminated

• Conditions: Neoplasm, Metastatic
• Interventions: Procedure: MRI with breath-holding

• Registration Number: NCT00178477
• Lead Sponsor: University of Rochester

Brief Summary

The purpose of this research study is to evaluate typical tumor motion caused by breathing using MRI and can help determine whether simple passive breathing and/or breath-holding could be used for the future treatment of similar lung and liver tumors using radiation therapy radiosurgery techniques.

Detailed Description

Not available

Study Timeline

• Study Start: 2002-01
• Study First Submitted: 2005-09-13
• Study First Submitted QC: 2005-09-13
• Study First Posted: 2005-09-15
• Primary Completion: 2011-01
• Study Completion: 2011-01
• Results First Submitted: 2011-08-12
• Status Verified: 2013-04
• Results First Submitted QC: 2013-04-18
• Last Update Submitted: 2013-04-18
• Results First Posted: 2013-04-19
• Last Update Posted: 2013-04-19

Recruitment & Eligibility

• Status: TERMINATED
• Sex: All
• Target Recruitment: 10

Inclusion Criteria

• The patient is enrolled on U8700 RSRB # A Phase II Study For Using Radiosurgery On Limited Metastases Of Breast Cancer or U9700 A Pilot Study For Using Radiosurgery On Limited Metastases.
• ≥ 18 years of age
• has given Informed consent

Exclusion Criteria

-Contraindications for any MRI procedure

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Breath-holding	MRI with breath-holding	MRI with breath-holding

Primary Outcome Measures

Name	Time	Method
Tumor Motion Related to Breathing as Determined From MRI Images	20 - 30 seconds	1. Determine the typical and maximal tumor 3D displacements over the respiratory cycle and how these values vary depending on the tumor location; 2. Determine the reproducibility of target position over multiple breath-holds; 3. Determine the variability across patients in respiratory-derived lesion motion and target position reproducibility over multiple breath-holds

Trial Locations

Locations (1)

University of Rochester Department of Radiation Oncology; 🇺🇸 Rochester, New York, United States