Acute Effects of High Flow Nasal Support During Exercise in Patients With COPD After Severe Exacerbation
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 19
- 试验地点
- 1
- 主要终点
- Difference in exercise capacity
研究概览
简要总结
Early pulmonary rehabilitation is recommended after an episode of severe exacerbation of chronic obstructive pulmonary disease (COPD). However, its implementation is challenging particularly as regard exercise training. High flow ventilation in reducing work of breathing and dyspnea may improve exercise tolerance. The aim of this study is to carry out the acute effect of high flow nasal cannula on exercise endurance in post-exacerbation copd patients
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 35 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •a diagnosis of COPD
排除标准
- •exercise contraindication Any musculoskeletal problems, cardiovascular or neurological comorbidities that limits exercise.
- •pH < 7,35
- •Body temperature > 38°C
- •cardiac frequency > 100 bpm at rest
- •systolic blood pressure < 100 mmHg
- •exacerbation during the study
研究组 & 干预措施
High Flow Nasal Test
Patients will perform one Constant Work-Rate Exercise Test at 80% of maximum workload with High Flow Nasal at 60L/min (with or without additional oxygen)
干预措施: High Flow nasal cannula (Device)
Control Test
Patient will perform one Constant Work-Rate Exercise Test at 80% of maximum workload on room air or with oxygen supplementation
结局指标
主要结局
Difference in exercise capacity
时间窗: The outcome will be measure after every CWRET. The two CWRET will be carried out in different days, separate from 24H minimum for a total time frame of 3 days maximum
Difference in endurance time (TLim) during High Intensity Constant Work-Rate Endurence Test (CWRET)
次要结局
- Difference in peripheral muscle oxygenation(The outcome will be measure during every CWRET. The two CWRET will be carried out in different days, separate from 24H minimum for a total time frame of 3 days maximum. Data will be continuously collected during exercise)
- Difference in Cardiac Frequency(The outcome will be measure during every CWRET. The two CWRET will be carried out in different days, separate from 24H minimum for a total time frame of 3 days maximum. Data will be continuously collected during exercise)
- Difference in Dyspnea and muscular fatigue(The outcome will be measure during every CWRET. The two CWRET will be carried out in different days, separate from 24H minimum for a total time frame of 3 days maximum. Data will be collected every 2 minute during tests and at the end of the exercise)
- Difference in Respiratory Muscle Fatigue(The outcome will be measure during every CWRET. The two CWRET will be carried out in different days, separate from 24H minimum for a total time frame of 3 days maximum. Data will be collected before and 5 minute maximum after exercise)
- Difference in Oxygen Saturation(The outcome will be measure during every CWRET. The two CWRET will be carried out in different days, separate from 24H minimum for a total time frame of 3 days maximum. Data will be continuously collected during exercise)
- Difference in Transcutaneous Carbon Dioxide(The outcome will be measure during every CWRET. The two CWRET will be carried out in different days, separate from 24H minimum for a total time frame of 3 days maximum. Data will be continuously collected during exercise)
- Difference in Respiratory Rate(The outcome will be measure during every CWRET. The two CWRET will be carried out in different days, separate from 24H minimum for a total time frame of 3 days maximum. Data will be continuously collected during exercise)