Immunophenotyping of inflammatory cells in Atopic Dermatitis

Withdrawn

• Conditions: Atopic dermatitis; eczema; 10001708; 10014982

• Registration Number: NL-OMON38740
• Lead Sponsor: niversitair Medisch Centrum Utrecht

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 29 April 2024

Recruitment & Eligibility

• Status: Withdrawn
• Sex: Not specified
• Target Recruitment: 0

Inclusion Criteria

1. AD group:
- age range 18 to 70 years
- AD according to diagnostic criteria of Hanifin and Rajka
- patients for APT: sensitised to aeroallergens (previously shown to have a positive APT)
2. Psoriasis group
- chronic plaque psoriasis patients, ages 18-70 years

Exclusion Criteria

- topical treatment of the biopsy region with corticosteroids or tacrolimus in the two weeks prior to taking the biopsies
- treatment with systemic corticosteroids or other immunosuppressive medication in the four weeks prior to taking the biopsies
- exposure of biopsy location to (extraordinary) UV sunlight (e.g. UV-therapy, sunny holiday) in in the two weeks prior to taking the biopsies

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>We will study the number of skin infiltrating cells per square millimetre skin<br /><br>in lesional AD skin, non-lesional AD skin, lesional psoriasis skin,<br /><br>non-lesional psoriasis skin and skin after atopy patch testing. This includes<br /><br>the analysis of:<br /><br>- T cells<br /><br>- B cells<br /><br>- NK cells<br /><br>- Dendritic cells<br /><br>- Eosinophils<br /><br>- Macrophages<br /><br>- Mast cells<br /><br>- Basophils<br /><br>- Neutrophils</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Not applicable</p><br>