The influence of sunitinib on contractility of human atrial trabeculae

Recruiting

• Conditions: cardiotoxicity; Heart failure; 10019280

• Registration Number: NL-OMON34277
• Lead Sponsor: niversitair Medisch Centrum Sint Radboud

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 6 May 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 60

Inclusion Criteria

• Age > 18 years
• Willing to sign informed consent
• Planned elective CABG surgery with extracorporal circulation

Exclusion Criteria

• Use of theophylline
• Use of sulfonylureas
• Use of oral antiarrhythmics
• Atrial arrhythmias
• Right ventricular failure

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The developed force in ex vivo atrial trabeculae during standardized<br /><br>stimulation.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>The difference in averaged maximal speed of tension development during<br /><br>contraction between two trabeculae.<br /><br>The difference in averaged maximal speed of tension reduction during relaxation<br /><br>between two trabeculae</p><br>