Probing neuroprotective effects of single session rTMS on subsequent mood and emotional processing

Completed

• Conditions: Depression; Major depressive disorder; 10027946

• Registration Number: NL-OMON40849
• Lead Sponsor: niversitair Medisch Centrum Sint Radboud

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 23 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 24

Inclusion Criteria

24 healthy, right-handed women using oral contraceptives and men (aged 18-35) with normal or corrected-to-normal vision

Exclusion Criteria

* Epilepsy, convulsion or seizure (TMS)
* Serious head trauma or brain surgery
* Large or ferromagnetic metal parts in the head (except for a dental wire)
* Implanted cardiac pacemaker or neurostimulator
* Pregnancy
* History or current presence of any neurologic or psychiatric disease
* Any prescribed medication that can alter cortical excitability (e.g. antiepileptics, tricyclic anti-depressives or benzodiazepines) or can have an influence on the participant*s vigilance or cognitive performance within two weeks prior to participation
* Color blind

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>To investigate the effect of rTMS and sham rTMS on mood as measured with<br /><br>changes in visual analogue scales and PANAS before and after negative mood<br /><br>induction. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>To investigate the effect of rTMS and sham rTMS on motivated attention for sad<br /><br>and facial expressions after sad mood induction. </p><br>