a clinical comparative study to evaluate the efficacy of kanchnar guggulu vatika and hamsapadiadi kashaya in the management of avatu granthi vikar w.s.r. hypothyroidism

Acharya Charaka categorize Hypothyroidism in Anukta Vyadhies means any disease which is not explained in Ayurvedic text but studied and treated on the basis of Kupit Dosha, Hetu, and their Sthan. The term Hypothyroidism is not mentioned directly in Ayurvedic texts, but the problems related to Thyroid Disorders were well described under the disorder known as Galaganda (Enlarged thyroid gland).

An analysis of the symptomatology of hypothyroidism, in the light of the Ayurvedic principle of Doshas & Dushya, showed in the Hypothyroidism there is a hypo activity of Agni at Koshta and Dhatu level with the analysis of  symptomatology of Hypothyroidism there’s a vatiation of Kapha-Vata Doshas . The lakshanas depend on the extent of involvement of Dhatus. So, the fundamental treatment principle in Hypothyroidism is to restore the Karmukata of Agni at both Kostha and Dhatu levels. This can be achieved through Ama Pachanam, Agni Deepanam, Srotosodhanam and administration of appropriate Rasayanam. Here Agni becomes diminished at the level of Dhatus and Sanga srotas which results in impairment of Dhatu function and leads to the symptoms as seen in hypothyroidism.[ By keeping all these things in my minds the select drugs will be fruitful in effective management of the disease rectifying Agnimandhya and Kapha-Medo dushti.

The volunteers will be informed about the study protocol and willing participants will be randomly selected as per the coin method. Clinical research format will be prepared and validated before the study approval will be taken from the IEC of the Shri NPA Govt. Ayurved College and hospital, Raipur C.G. and CTRI registration will be done. After selection, each participant will be tasted individually and selected according to the assessment criteria. Sixty patients of Avatu Granthi Vikar will be selected from Kayachikitsa OPD and IPD Shrihri NPA government Ayurved college and hospital, Raipur C.G. The

case selection was in regards to age, sex, occupation, and socio-economic conditions. Both acute and chronic phases of Avatu Granthi Vikar patients were taken for the study, following the WHO scoring of Ayurveda Symptoms’s criteria for diagnosing Avatu Granthi Vikar as well as the clinical features of Hypothyroidism described in modern medicine. The present study is a single-center, open-labeled randomized (coin method) clinical trial. A total of 60 clinically diagnosed and registered patients of  Hypothyroidism were divided randomly by coin method into three groups. Each group will have 20 patients. Group A: 20 clinically diagnosed patients of Hypothyroidism will be treated with Kanchnar Guggulu Vatika 2 tablets (each 500 mg) two times in a day with lukewarm water before meal for 90 days. Group B: 20 clinically diagnosed patients of Hypothyroidism were treated with Hmasapadiadi Kashaya 40 ml two times in a day before meal with anupana madhu for 90 days along. Group C: 20 patients diagnosed with Avatu Granthi Vikar were treated with both trial drugs Kanchnar Guggulu Vatika (2Tab) and Hamsapadiadi Kashaya (40ml) two times a day before meal.