Is Preoperative Pain Response Upon Tonic Heat Stimulation Predictive for Pain After Total Knee Arthroplasty?
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- Cumulated pain (from 0-24 hours after surgery)
研究概览
简要总结
In this consecutive, prospective cohort study trial the investigators evaluate if preoperative pain response upon heat stimulation is predictive for acute and subacute postoperative pain after total knee arthroplasty.
详细描述
The preoperative heat stimulation consists of short and long tonic heat stimulation. Pain response is evaluated with an electronic visual analog scale.
Furthermore the investigators evaluate other factors possibly predictable for acute and subacute postoperative pain after total knee arthroplasty - demographic factors, preoperative pain related factors, psychosocial factors (Hospital Anxiety and Depression Scale and Pain Catastrophizing Scale).
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Ethnic danes, above 18 years and able to give informed consent scheduled for primary, unilateral total knee arthroplasty.
排除标准
- •Bilateral / revision arthroplasty
- •Disease affection central or peripheral nerve function
- •Alcohol and medical abuse
- •Daily use of opioids or glucocorticoids
- •Malignancy
- •BMI > 40
- •Depression
- •Dementia or other cognitive dysfunction
结局指标
主要结局
Cumulated pain (from 0-24 hours after surgery)
时间窗: 24 hours
Pain during walk 5 m (VAS)
次要结局
- Cumulated pain (from day 1 to day 7 after surgery)(7 days)
- Pain at day 14 after surgery(14 days)
- Pain at day 30 after surgery(30 days)
研究者
Troels Haxholdt Lunn
MD
Hvidovre University Hospital