Temozolomide plus bevacizumab for newly-diagnosed glioblastoma in the elderly over 75
Phase 1
Recruiting
- Conditions
- glioblastoma, high-grade glioma
- Registration Number
- JPRN-UMIN000014678
- Lead Sponsor
- Department of Neurosurgery, Keio University School of Medicine
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 10
Inclusion Criteria
Not provided
Exclusion Criteria
1) presence of active infection that needs systemic treatment 2) history of cranial irradiation 3) hemorrhagic diathesis, coagulation disorder (anticoagulant/antiplatelet drugs are permitted) 4) serious cardiac disorder 5) history of myocardial infarction, cerebral infarction, deep vein thrombosis, or pulmonary embolism within 6 months 6) history of symptomatic intracranial hemorrhage within 6 months 7) uncured wound 8) poor control hypertension 9) serious, active peptic ulcer 10) pulmonary fibrosis or interstitial pneumonia
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method safety
- Secondary Outcome Measures
Name Time Method overall survival, progression-free survival