Analgesic Effect of a New Metamizol Oral Pharmaceutical Form for the Treatment of the Neoplastic Chronic Pain: Randomized, Double-blind Crossover Clinical Trial Between Metamizol, Diclofenac and Placebo
试验速览
- 阶段
- 4 期
- 状态
- 终止
- 入组人数
- 6
- 主要终点
- Change in morphine requirement
研究概览
简要总结
Study to evaluate the efficacy of metamizole in reducing morphine requirements in patients with moderate to severe chronic cancer pain in comparison to administration of placebo or diclofenac.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Treatment
- 盲法
- Double
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Hospitalized patients with neoplastic chronic pain requiring morphine treatment
排除标准
- •Karnofsky index less than 30%
研究组 & 干预措施
Metamizole - Diclofenac
metamizole followed by diclofenac
干预措施: Diclofenac (Drug)
Metamizole - Diclofenac
metamizole followed by diclofenac
干预措施: Metamizole (Drug)
Metamizole - Diclofenac
metamizole followed by diclofenac
干预措施: Diclofenac placebo (Drug)
Metamizole - Diclofenac
metamizole followed by diclofenac
干预措施: Metamizole placebo (Drug)
Diclofenac - Metamizole
diclofenac followed by metamizole
干预措施: Metamizole (Drug)
Diclofenac - Metamizole
diclofenac followed by metamizole
干预措施: Diclofenac (Drug)
Diclofenac - Metamizole
diclofenac followed by metamizole
干预措施: Diclofenac placebo (Drug)
Diclofenac - Metamizole
diclofenac followed by metamizole
干预措施: Metamizole placebo (Drug)
Metamizole - Placebo
metamizole followed by placebo
干预措施: Metamizole (Drug)
Metamizole - Placebo
metamizole followed by placebo
干预措施: Diclofenac placebo (Drug)
Metamizole - Placebo
metamizole followed by placebo
干预措施: Metamizole placebo (Drug)
Placebo - Metamizole
placebo followed by metamizole
干预措施: Metamizole (Drug)
Placebo - Metamizole
placebo followed by metamizole
干预措施: Diclofenac placebo (Drug)
Placebo - Metamizole
placebo followed by metamizole
干预措施: Metamizole placebo (Drug)
结局指标
主要结局
Change in morphine requirement
时间窗: Baseline, 9 days
次要结局
未报告次要终点