Th17 Inducing Cytokines Pregnancy and After Postpartum

Completed

• Conditions: Pregnancy
• Interventions: Other: Saliva collection; Other: GCF collection

• Registration Number: NCT03449186
• Lead Sponsor: Aydin Adnan Menderes University

Brief Summary

The aim of this study was to investigate salivary and gingival crevicular fluid (GCF) levels of IL-17A, IL-17E, IL-6 AND IL-23 during 2/3 trimester of pregnancy and after delivery.

Detailed Description

IL-17 have a synergytic effect with IL-6 and IL-23. IL-17A levels elevated with periodontal diseases. Many systemical chronic conditions such as atherosclerosis and cardiovascular disease, pregnancy may contribute increasing of IL-17 family cytokine.

Study Timeline

• Study Start: 2013-04-01
• Primary Completion: 2014-04
• Study Completion: 2018-01
• Study First Submitted: 2018-01-26
• Status Verified: 2018-02
• Study First Submitted QC: 2018-02-22
• Last Update Submitted: 2018-02-22
• Study First Posted: 2018-02-28
• Last Update Posted: 2018-02-28

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 114

Inclusion Criteria

• women 2 and 3 trimester of their pregnancy

Exclusion Criteria

• any known systemic disease,
• periodontal treatment within the last six months,
• patients having less than 10 teeth,
• smokers,
• individuals with a BMI > 30 kg/m2,
• gestational diabetes and preeclampsia during pregnancy.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Postpartum group	Saliva collection	Postpartum women 6 months after giving birth recalled. Saliva and GCF samples were collected and clinical periodontal measurements were made.
Postpartum group	GCF collection	Postpartum women 6 months after giving birth recalled. Saliva and GCF samples were collected and clinical periodontal measurements were made.
Pregnancy group	Saliva collection	Women, who were in their second trimester (weeks 16-24) or third trimester (weeks 25-34)selected for the study. Saliva and GCF samples were collected and clinical periodontal measurements were made gently
Pregnancy group	GCF collection	Women, who were in their second trimester (weeks 16-24) or third trimester (weeks 25-34)selected for the study. Saliva and GCF samples were collected and clinical periodontal measurements were made gently

Primary Outcome Measures

Name	Time	Method
Changing Il-17A levels	6 month	Salivary and GCF level measured by ELISA

Secondary Outcome Measures

Name	Time	Method
Changing IL-6 levels	6 month	Salivary and GCF level measured by ELISA
Changing IL-23 levels	6 month	Salivary and GCF level measured by ELISA
Changing IL-17E levels	6 month	Salivary and GCF level measured by ELISA