Effects of Age on Amino Acid Delivery to Tendon

Not Applicable

Completed

• Conditions: Aging
• Interventions: Dietary Supplement: Amino Acids

• Registration Number: NCT04064528
• Lead Sponsor: Purdue University

Brief Summary

Dietary amino acid supplementation may provide an effective means to promote tendon injury recovery and enhance collagen synthesis. While most published research has been completed in animal models, research with young adults has shown that a leucine-rich whey isolate consumed during a chronic resistance training (RT) intervention resulted in greater gains (\~60%) in tendon CSA when compared to placebo. Leucine-rich diets have also improved tendon collagen content in rodents. Further, in our preliminary work utilizing microdialysis, we demonstrate that oral consumption of a leucine-rich amino acid beverage increased delivery of amino acids to tendons in young adults (21-30 years). However, whether aging alters the delivery of amino acids to tendons after oral consumption has not be investigated. In order to optimize amino acid dosing for chronic interventional studies, we wish to determine if aging influences amino acid concentration in the peritendinous (space around the tendon) space after oral consumption.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2019-08-20
• Study First Submitted QC: 2019-08-20
• Study First Posted: 2019-08-22
• Study Start: 2019-09-06
• Primary Completion: 2022-08-01
• Study Completion: 2023-08-01
• Status Verified: 2023-12
• Last Update Submitted: 2023-12-13
• Last Update Posted: 2023-12-14

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

Exclusion Criteria

• body mass index >35 kg•m-2, those on medications known to affect protein or collagen metabolism, e.g. acetaminophen, ibuprofen, or prescription cyclooxygenase inhibitors, previous history of tendinopathy, or diabetes.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: FACTORIAL

Arm && Interventions

Group	Intervention	Description
Older Adults	Amino Acids	Older adults will be given a 10 g oral bolus of amino acids.
Young	Amino Acids	Young adults will be given a 10 g oral bolus of amino acids.

Primary Outcome Measures

Name	Time	Method
Achilles Peritendinous Amino Acid Levels in young and older adults	0-6 hours post consumption	Concentrations of amino acids will be measured from around the Achilles tendon

Trial Locations

Locations (1)

Purdue University; 🇺🇸 West Lafayette, Indiana, United States