The Feasibility and Safety of Head-up Cardiopulmonary Resuscitation in Patients With Non-traumatic Cardiac Arrest

Not Applicable

Recruiting

• Conditions: Cardiac Arrest
• Interventions: Device: Head-up Cardiopulmonary Resuscitation

• Registration Number: NCT05609357
• Lead Sponsor: National Taiwan University Hospital

Brief Summary

Head up CPR with impedance threshold device(ITD) and active compression-decompression (ACD) has been proved to improve both cerebral and coronary perfusion pressure during resuscitation in animal models. Increased rates of Spontaneous Circulation (ROSC) were also observed in cardiac arrest patients.

The goal of this clinical trial is to learn about the feasibility and safety of Head-up Cardiopulmonary Resuscitation in patients with non-traumatic cardiac arrest. Participants will be received head-up CPR during resuscitation. The main question it aims to answer is if there is any adverse or unfavorable event during resuscitation.

Detailed Description

Not available

Basic Information
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Recruitment & Eligibility
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Study & Design
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Trial Locations

Study Timeline

• Study First Submitted: 2022-10-19
• Study First Submitted QC: 2022-11-03
• Study Start: 2022-11-04
• Study First Posted: 2022-11-08
• Status Verified: 2023-08
• Last Update Submitted: 2023-08-08
• Last Update Posted: 2023-08-09
• Primary Completion: 2023-12-31
• Study Completion: 2023-12-31

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

• Non-traumatic cardiac arrest
• Age ≥ 20

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Exclusion Criteria

• Trauma
• Age < 20
• Pregnancy
• Irreversible death (e.g. liver mortis, rigor mortis, decapitation, transection and decomposition)
• Disorder of cervical spine

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Head-up Cardiopulmonary Resuscitation	Head-up Cardiopulmonary Resuscitation	-

Primary Outcome Measures

Name	Time	Method
Number and portion of participants with serious or non-serious adverse event	Up to 1 day	e.g. event of fall, failure of intubation

Secondary Outcome Measures

Name	Time	Method
Number and portion of participants with repeated CPR	up to 1 day
Number and portion of participants with sustained return of spontaneous circulation	Up to 1 day	sustained ROSC ≥ 20 minutes
Number and portion of participants with survival to emergency department discharge	up to 1 day

Trial Locations

Locations (1)

National Taiwan University Hospital; 🇨🇳 Taipei, Taiwan