Relationships of B-cell Activating Factor Gene Polymorphisms With the Risk and Clinicopathological Features of Crohn's Disease.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 824
- 试验地点
- 1
- 主要终点
- the genotypes of BAFF
研究概览
简要总结
From January 2020 to December 2024, Crohn's disease(CD) patients and gender- and age-matched normal controls were collected from the Department of Gastroenterology, the Second Affiliated Hospital of Wenzhou Medical University. The aim of this research is to explore the associations of B-cell activating factor(BAFF) gene polymorphisms with the risk and clinicopathological characteristics of CD.
详细描述
From January 2020 to December 2024, a total of 310 CD patients and 514 gender- and age-matched normal controls were collected from the Department of Gastroenterology, the Second Affiliated Hospital of Wenzhou Medical University.The genotypes of BAFF were determined by multiplex polymerase chain reaction-ligase detection reaction technique. Unconditional logistic regression was employed to analyze the distribution of BAFF gene polymorphisms between CD group and normal control group, as well as their influences on the clinicopathological characteristics of CD patients.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •diagnosed CD based on comprehensive clinical, colonoscopy, histopathological, laboratory, and radiographic examination results
排除标准
- •rheumatoid arthritis, systemic lupus erythematosus, intestinal tuberculosis, ischemic enteritis, radiation enteritis, tumors, etc
研究组 & 干预措施
CD patients
Patients diagnosed with Crohn's disease
normal controls
gender- and age-matched normal controls
结局指标
主要结局
the genotypes of BAFF
时间窗: Baseline
multiplex polymerase chain reaction-ligase detection reaction technique
次要结局
未报告次要终点