A comparison of pulse pressure variability and inferior vena cava dispensability index for predicting fluid responsiveness
Not Applicable
- Conditions
- Health Condition 1: - Health Condition 2: G939- Disorder of brain, unspecified
- Registration Number
- CTRI/2024/04/064995
- Lead Sponsor
- TNMC and BYL Nair Ch. Hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
Patients posted for routine major surgeries in plastic and neurosurgery OT under general anaesthesia and mechanical ventilation
Arterial cannulation done as a part of routine protocol
ASA 1 and 2
Exclusion Criteria
Pregnancy,
Patients with cardiac and respiratory ailments
Raised intracranial pressure
Contraindication of fluid challenge (acute coronary syndrome, cardiac shock, and evidence of
capacity overload)
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Accuracy of PPV in predicting volume responsiveness can be increased by increasing TV. Optimal TV that enables best diagnostic value is 10 ml/kg. The diagnostic value of PPV is higher than that of IVC DI.Timepoint: TV adjustment will be carried out after about 10 min when the hemodynamics of the patient <br/ ><br>become stable. <br/ ><br>The TV will be adjusted to 8 mL/kg. <br/ ><br>The parameters will be recorded. <br/ ><br>The TV will be adjusted to 10 mL/kg after 2 min. <br/ ><br>The indices will be recorded after maintenance for 2 min. <br/ ><br>Then Fluid challenge will be given. <br/ ><br>The tidal volumes of 8 and 10 mL/kg will be adjusted immediately after the fluid challenge and <br/ ><br>maintained for 2 min, and then the above indices will be recorded again. <br/ ><br>
- Secondary Outcome Measures
Name Time Method Changes in VTI with fluid challengeTimepoint: TV adjustment will be carried out after about 10 min when the hemodynamics of the patient <br/ ><br>become stable. <br/ ><br>The TV will be adjusted to 8 mL/kg. <br/ ><br>The parameters will be recorded. <br/ ><br>The TV will be adjusted to 10 mL/kg after 2 min. <br/ ><br>The indices will be recorded after maintenance for 2 min. <br/ ><br>Then Fluid challenge will be given. <br/ ><br>The tidal volumes of 8 & 10 mL/kg will be adjusted immediately after the fluid challenge and <br/ ><br>maintained for 2 min, & then the above indices will be recorded again. <br/ ><br>